ADM-RAMP2 System (IMAGE)

Elsevier

ADM-RAMP2 System

Caption

A: Topical endoscopy fundus imaging showing the ocular fundus of untreated and central retinal vein occlusion (CRVO)-treated mice (day 7). In the CRVO-treated mice, note the retinal hemorrhage and venous dilatation with tortuousness resembling clinical CRVO. B: Retinal flat-mount images of untreated and CRVO-treated mice (day 7). In the CRVO-treated mice, retinal hemorrhage is prominent. C: Fluorescein isothiocyanate (FITC)-perfused retinal flat-mount images analyzed using AngioTool software in wild-type (WT), Adm knockout (ADM KO), and Ramp2 knockout (RAMP2 KO) mice after CRVO treatment (day 7). Blood vessels are depicted in red, and vascular branch points are depicted in blue. D: Percent vascular area in FITC-perfused retinal flat-mounts quantified using AngioTool. E: FITC-perfused retinal flat-mounts analyzed using AngioTool software in control (Ctrl) and ADM-administered (ADM pump) mice after CRVO treatment (day 7). Blood vessels are depicted in red, and vascular branch points are depicted in blue. F: Percent vascular area in FITC-perfused retinal flat-mounts quantified using AngioTool.

Credit

<i>American Journal of Pathology</i>

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