HEK Beta Cell (IMAGE) ETH Zurich Caption Diagram of a HEK-beta cell. Extracellular D-glucose triggers glycolysis-dependent membrane depolarization, which activates the voltage-gated calcium channel, resulting in an influx of Calcium ions, induction of the calmodulincalcineurin signaling cascade, and PNFAT-mediated induction of insulin secretion. Credit ETH Zurich Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.