TRANSLATION 1 (IMAGE)

Rice University

TRANSLATION 1

Caption

Rice University scientists found the organized structure of mRNA/prion aggregates provides a new route to regulation of translation activity. At top, a CPEB protein binds to the 3’ (aka 3 prime) terminal of a target mRNA using an RNA-binding domain (RBD). The prion aggregate forms a translation assembly line in which ribosomes are efficiently recycled. After translation is complete, the ribosomes are released from the mRNA 3’ end and diffuse outwards to be recruited again by the 5’ ends at the outer layer of the assembly. At bottom, the structure of the mRNA and Rim4 aggregates displays the opposite polarity and represses translation. Rim4 RBD binds with the 5’ terminal of target mRNAs.

Credit

Xinyu Gu/Rice University

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