Figure 1. CLIP-170 Phosphorylation Regulates MTOC Repositioning and Full Activation of T Cells (IMAGE)

Tokyo Institute of Technology

Figure 1. CLIP-170 Phosphorylation Regulates MTOC Repositioning and Full Activation of T Cells

Caption

Fluorescence live-cell imaging of the wild-type CLIP-170-TagRFP-T (a,b) or a phosphodeficient S312A mutant CLIP-170-TagREP-T (c) and dynein light chain (DLC)-mEGFP co-expressed in T cells. Increased dynein relocation to the center, which is responsible for MTOC repositioning, requires both stimulation and CLIP-170 phosphorylation. The boxed regions in the merged images are enlarged (right). Scale bars: 5 μm (left, 2nd left, merged) and 2 μm (right).

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<i>Scientific Reports</i>

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