Spleen MZ B Cells Contribute to Inflammatory Response Against Endotoxins (IMAGE)

University of Tsukuba

Spleen MZ B Cells Contribute to Inflammatory Response Against Endotoxins

Caption

B cells from the marginal zone (MZ) of the spleen produce high levels of the pro-inflammatory cytokine interleukin-6 (IL-6) in response to bacterial endotoxins. This response is coordinated by a signaling reaction involving TLR4 and Fcα/µR, and leads to systemic inflammation and endotoxic shock.

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University of Tsukuba

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