Targeting Tau (IMAGE) University of Pennsylvania School of Medicine Caption Progressive microglial activation in the central nervous system of transgenic tau mice. Microglia are progressively activated with age in the brains of transgenic mice (PS19, three to nine months) compared to normal mice (nTg). Credit Virginia Lee, Ph.D., University of Pennsylvania School of Medicine; Neuron Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.