Signs and symptoms of frailty (IMAGE) Johns Hopkins Medicine Caption Diagnosis of frailty is based on three or more of five key clinical signs and symptoms: weakness, slow walking speed, low level of physical activity, fatigue or exhaustion, and unintentional weight loss. Credit Jennifer Fairman Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.