Pancreatic Tumor-Associated Fibroblasts (IMAGE)
Caption
In the dense stromal tissue that envelops pancreatic tumors, Tuveson and colleagues have discovered two varieties of a cell type called fibroblasts which help create the stroma. One of these varieties is seen in left image: fibroblasts (red) close to proliferating cancer cells (green) that express high levels of a protein called aSMA. In the image at right, red color indicates the presence of the immune-signaling molecule IL6, which a second subclass of tumor-related fibroblasts secretes. These fibroblasts do not express aSMA, and tend to be farther from the tumor. These images, from pancreatic organoids grown in 3D culture, recapitulate the same heterogeneity in tumor-associated fibroblasts first seen by the team in samples derived from people with pancreatic tumors. Selectively targeting fibroblast subtypes may increase the ability of currently available chemotherapy drugs to reach and reduce pancreatic tumors
Credit
Tuveson Lab, CSHL
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