The core molecular network shared by Alzheimer’s disease and frontotemporal lobar degeneration. (IMAGE)

Tokyo Medical and Dental University

The core molecular network shared by Alzheimer’s disease and frontotemporal lobar degeneration.

Caption

Supercomputer-based dynamic molecular network analysis predicted HMGB1-TLR4 induced signal as the most important target of two major neurodegenerative dementias. The prediction was verified by significant phenotypic and pathological improvements of four types of mouse model of frontotemporal lobar degeneration treated by anti-HMGB1 antibody.

Credit

Department of Neuropathology, TMDU

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