The SARS-CoV-2 receptor-binding domain (IMAGE) Rockefeller University Press Caption The SARS-CoV-2 spike protein drives the virus’s entry into cells because its receptor-binding domain—consisting of a head region (red) and a core region (blue)—binds to the human ACE2 protein (gray). Credit © 2021 Shinnakasu et al. Originally published in Journal of Experimental Medicine. https://doi.org/10.1084/jem.20211003. Usage Restrictions Credit must be given to the creator. Only noncommercial uses of the work are permitted. Adaptations must be shared under the same terms. License CC BY-NC-SA Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.