Follicular Helper T Cells (IMAGE)

La Jolla Institute for Immunology

Follicular Helper T Cells

Caption

Follicular helper T cells (Tfh cells, shown in blue) play a crucial role in the maturation of antibody-producing B cells (shown in green). Activated B cells give rise germinal centers (shown in red), where mature B cells proliferate and produce highly specific antibodies against pathogens. Top left: normal germinal center in a mouse tonsil. All others: Germinal centers fail to form when the interaction between ICOS and TBK1 is interrupted.

Credit

Courtesy of Dr. Kok-Fai Kong at La Jolla Institute for Allergy and Immunology and Nature Immunology.

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