Model of Psoriasis Pathogenesis (IMAGE) Hokkaido University Caption Psoriasis is a chronic immune-mediated inflammatory disorder. IL-17A and other cytokines act on keratinocytes to activate further inflammatory mediator production, thereby creating an inflammatory loop. Credit Ryuta MUROMOTO, Hokkaido University Usage Restrictions The image may only be used with appropriate caption or credit. License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.