Mechanism of Selection of Memory B Cells and Plasma Cells from Germinal Center B Cells (IMAGE)
Caption
The affinity of B cell receptor for antigen and the expression level of Bach2 are inversely correlated in germinal center B cells. Low affinity germinal center B cells, which receive weaker stimulation from antigen and antigen specific CD4 T cells, maintain a relatively high level of Bach2 expression and tend to be induced to form memory B cells in the germinal center. On the other hand, high affinity cells, which receive strong stimulation from antigen and antigen specific CD4 T cells, have difficulty maintaining Bach2 expression at high levels and tend to be induced to form plasmablasts (plasma cells).
Credit
Osaka University
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