Exon Skipping Treatment for Allergic response (IMAGE)

North Carolina State University

Exon Skipping Treatment for Allergic response

Caption

Left: mast cells are activated by allergens reacting with IgE bound to IgE receptors on the mast cell surface to trigger the release of histamine and other inflammatory mediators that orchestrate an allergic response including recruitment of inflammatory cells. Right: exon skipping treatment eliminates trafficking of the IgE receptor to the surface of mast cells, rendering the cells unresponsive to allergen-mediated mast cell activation.

Credit

Glenn Cruse

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