Meta-analyses of RAPID trial and multiplatform trial in moderately ill ward patients (IMAGE)

Larner College of Medicine at the University of Vermont

Meta-analyses of RAPID trial and multiplatform trial in moderately ill ward patients

Caption

Squares and horizontal lines show treatment effects and their 95% confidence intervals in each trial. The area of each square is proportional to the weight the trial received in the meta-analysis. Diamonds show estimated treatment effects and 95% confidence intervals from meta-analyses. Odds ratios for ventilator-free and organ support-free days alive are from ordinal logistic regression in both trials; death was assigned the worst outcome (a value of -1). Major thrombotic events were defined as the composite of myocardial infarction, pulmonary embolism, ischemic stroke or systemic arterial embolism; Major bleeding defined by the ISTH Scientific and Standardization Committee. In accordance with the primary outcome definition of the multiplatform trials, organ support-free days alive were calculated for an observation time of 21 days; remaining outcomes were based on an observation time of 28 days.

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Courtesy of M. Sholzberg

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