A Kiss of Death to Drug the 'Undruggable' (IMAGE)

University of Dundee

A Kiss of Death to Drug the 'Undruggable'

Caption

Image shows the E3 ligase protein VHL (in grey) in complex with the small molecule MZ1 (in raspberry) and 'kissing' the protein BRD4 (in yellow). Upon receiving this deadly `kiss', BRD4 is targeted for degradation.

Credit

Xavier Lucas, Alessio Ciulli, University of Dundee

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