TALEN (IMAGE) Duke University Caption The TALEN finds its target site in the human genome by binding to DNA, shown in green, with an engineered DNA-recognition protein, shown in orange. Once the protein finds its target site, the DNA is modified by the enzyme domain of the protein shown in blue. Credit Charles Gersbach Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.