Design Of Antibody-Like T Cell Receptor To Target Virally-Infected Cells (IMAGE)
Caption
T cells are adept at killing cytomegalovirus (CMV)-infected cells by virtue of a T cell receptor (TCR) that recognizes intracellular CMV-associated proteins that become presented on the cell surface. By contrast, antibodies float freely through the body, binding tightly to secreted and membrane proteins and tagging them for recognition by other immune cells. This work combined the cell targeting properties of a TCR and the tight binding of an antibody with other modifications to create a new molecule able to detect and tag CMV-infected cells. This hybrid protein represents a new strategy to identify and possibly eliminate CMV-infected cells.
Credit
Jennifer Maynard/Ellen Wagner/University of Texas
Usage Restrictions
Attribution to Jennifer Maynard/Ellen Wagner/University of Texas
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