Figure (IMAGE)

Kanazawa University

Figure

Caption

Upper panel: MTHFD2 is abundantly expressed in the mitochondria in cancer cells. Active MTHFD2-mediated one-carbon metabolism consumes AICAR and produces IMP and purine nucleotides for cancer cell proliferation. Reduced intracellular pool of AICAR is essential for maintenance of cancer stem-like cells and their growth. Lower panel: When MTHFD2 expression is inhibited, cancer cell proliferation is inhibited due to reduced production of IMP and purine nucleotides and cancer stem-like cells are reduced due to increase levels of AICAR.

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Kanazawa University

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