TDP-43 simulation (IMAGE)

Lehigh University

TDP-43 simulation

Caption

A snapshot of the TDP-43 simulation highlighting the formation of oligomers mediated by helix-helix contacts (magenta). (A. E. Conicella, G. L. Dignon, G. H. Zerze, H. B. Schmidt, A. M. D'Ordine, Y. C. Kim, R. Rohatgi, Y. M. Ayala, J. Mittal, N. L. Fawzi. TDP-43 α-helical structure tunes liquid-liquid phase separation and function. Proceedings of the National Academy of Sciences 117, 5883-5894 (2020). DOI: 10.1073/pnas.1912055117)

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Figure reproduced with permission from Proceedings of the National Academy of Sciences USA.

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