How Immune Systems Change During Aging (IMAGE) Cincinnati Children's Hospital Medical Center Caption Undesired excessive Interleukin-10 (IL-10) production in aged mice comes primarily from Tfh cells, according to new findings published in Science Advances. This chart shows that when these cells are stimulated with IL-21, the percentage of IL-10 producing cells rises to 21% in older mice, but just to 9% in younger mice. Credit Cincinnati Children's Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.