Medulloblastoma Cells (IMAGE)

Massachusetts General Hospital

Medulloblastoma Cells

Caption

Medulloblastoma cells secrete the developmental protein Shh, which binds to receptors in stromal cells and triggers signaling that leads to the production of PlGF. Stromal-derived PlGF then binds to Nrp1 receptors in the cancer cell and conveys signals that sustain the growth and spread of the tumor.

Credit

Lance Munn, Ph.D., and Nathaniel Kirkpatrick, Ph.D., Steele Laboratory for Tumor Biology, Massachusetts General Hospital.

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