DNA Double-Strand Breaks (IMAGE)

Osaka University

DNA Double-Strand Breaks

Caption

These are DNA double-strand breaks, introduced by ionizing radiation or other mechanisms, are repaired rapidly and precisely in normal cells (right pathway). In contrast, compromised Tel1 activation with inefficient end joining activity in the mutant promotes accumulation of Ku protein at single-stranded DNA ends at the damaged site, and then, results in imprecise repair of genomic DNA (left pathway).

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Osaka University

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