Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes (IMAGE)

Nagoya University

Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes

Caption

Fused in sarcoma (FUS) and its binding partner proline- and glutamine-rich (SFPQ) regulates Mapt splicing, resulting balanced ratio of tau isoforms. Loss of interaction between FUS and SFPQ alters Mapt splicing, and subsequently increases 4-repeat tau/ 3-repeat tau ratio. This unbalanced tau isoform ratio leads to a neurodegenerative phenotype similar to FTLD.

Credit

Yusuke Fujioka, Shinsuke Ishigaki, and Gen Sobue

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.