Microglial changes in response to antibiotics (IMAGE)

University of Chicago Medical Center

Microglial changes in response to antibiotics

Caption

Microglia in the brain of male mice with Alzheimer’s Disease have a “neurodegenerative” appearance and is associated with amyloid beta plaques in the brain (left), while treating the mice with antibiotics early in life leads to “neuroprotective” microglia and reduced amyloidosis (middle). The beneficial effects of antibiotics can be reversed with a simple fecal matter transplant (right).

Credit

From Dodiya et al., Journal of Experimental Medicine 2021

Usage Restrictions

May only be used for stories describing this specific research

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.