RNAP and Inhibitors (IMAGE)

Rutgers University

RNAP and Inhibitors

Caption

Crystal structures of Mtb RNAP bound to rifampin (left), Mtb RNAP bound to an AAP (center), and Mtb RNAP bound to both rifampin and an AAP (right) show that rifampin and the AAP interact with non-overlapping binding sites on Mtb RNAP and, as a result, can bind simultaneously to Mtb RNAP. Gray and cyan ribbons, Mtb RNAP; yellow and orange ribbons, transcription initiation factor sigma; red and pink ribbons, DNA (specific sequence elements in blue).

Credit

Wei Lin and Richard H. Ebright

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