Engineered Protein Facilitates Destruction of Latently HIV-Infected Immune Cells (IMAGE)
Caption
This is an illustration of how the engineered protein facilitates destruction of latently HIV-infected immune cells. 1) Protein and cells, from left to right: engineered protein with yellow-and-black CD3-binding end and thick black HIV-binding end; latently HIV-infected helper T cell (blue); inactivated killer T cell (red). 2) Protein binds to CD3 receptor on helper T cell, activating it so the helper T cell starts making HIV and displaying pieces of virus (red) on its surface. 3) Protein binds to HIV fragment on helper T cell and CD3 receptor on killer T cell, activating the killer T cell and bringing the two cells close together. 4) Activated killer T cell destroys HIV-infected helper T cell.
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NIAID
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