Balancing Act: Cell Senescence, Aging Related to Epigenetic Changes (IMAGE)

University of Pennsylvania School of Medicine

Balancing Act: Cell Senescence, Aging Related to Epigenetic Changes

Caption

When comparing gains and losses of two histone modifications, there were large-scale domains of enriched histone modifier "mesas" and depleted histone modifier "canyons," as graphically depicted when comparing the gains and losses. The enriched "mesas" form at lamin B1-associated areas on the chromatin.

Credit

Parisha Shah, PhD; Shelley Berger, PhD, Perelman School of Medicine, University of Pennsylvania; <i>Genes & Development</i>

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