Pseudouridimycin and Rifampin (IMAGE)

Rutgers University

Pseudouridimycin and Rifampin

Caption

Structure of bacterial RNA polymerase, showing the binding sites for the new antibiotic pseudouridimycin (PUM) and the current antibacterial drug rifampin (Rif). PUM has a lower resistance rate and a smaller resistance target than Rif -- just 2 to 4 positions where alterations that result in PUM-resistance (blue) vs. 27 positions where alterations result in Rif-resistance (red) -- due to functional constraints on alteration of the binding site for PUM in the RNA polymerase active center.

Credit

David Degen and Richard H. Ebright (Rutgers University)

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