Pinpointing a Therapuetic RNA that Corrects a Splicing Error (IMAGE)

Cold Spring Harbor Laboratory

Pinpointing a Therapuetic RNA that Corrects a Splicing Error

Caption

Adrian Krainer's team at CSHL tested many synthetic RNA molecules in order to find one that most efficiently corrected the RNA splicing error that causes FD. Each of the tested candidate RNAs is represented by a horizontal line; thickness of the lines correlates with the strength of their impact. Red lines: exacerbated the splicing error; Blue lines: had no impact on the error; Green lines: alleviated the splicing error. The region tested includes three of the protein-coding regions, or exons, of the IKBKAP gene (exons 19, 20 and 21), and the intervening regions, or introns, which are eventually spliced away. The candidate RNA binds at a short intronic region immediately following exon 20 (ISS-40).

Credit

Krainer Lab, CSHL

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.