Figure (IMAGE)

Kanazawa University

Figure

Caption

A schema summarizing the effects caused by the deficiency of GABAergic transmission from vasopressin neurons on circadian rhythms at multiple levels. Without GABA release from vasopressin neurons, the spatiotemporal pattern of GABAergic transmission alters within the SCN. Such an alteration does not significantly disturb the spatiotemporal organization of molecular clocks measured with clock gene expression and intracellular calcium, but it does cause an aberrant bimodal pattern of the SCN firing (electrical activity) rhythm that may lead to the increased interval between the morning and evening locomotor activities. Thus, GABAergic transmission of vasopressin neurons regulates the SCN neuronal activity rhythm to modulate the time at which SCN molecular clocks enable circadian behavior.

Credit

Kanazawa University

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