Future transfusion therapy using RBCs produced from immortalized cell lines (IMAGE)
Caption
Hematopoietic stem cells isolated from various sources such as bone marrow and umbilical cord blood are differentiated to erythroblasts, immature red blood cells that still hold a nucleus. These cells are then transduced with virus expressing HPV-E6/E7 to be immortalized. Established cell lines can be easily maintained and expanded infinitely. At a desired time, those cells are placed into a different culture condition to mature toward RBCs, which are then used for transfusion.
Credit
Dr. Kenichi Miharada
Usage Restrictions
To use this media elsewhere, the authors request that a reference to this release be included.
License
Original content