Graphical Abstract (IMAGE) Tokyo Metropolitan Institute of Medical Science Caption In Drosophila, octopamine signaling increases larval locomotor speed and synaptic bouton numbers at neuromuscular junctions under food deprivation conditions. We found that a glypican (Dally-like), the expression of which is controlled by octopamine signaling, regulates this process by modulating the activity of GluRIIA-mediated non-canonical BMP pathway. Credit Tokyo Metropolitan Institute of Medical Science Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.