Yin and Yang of Raf Inhibition (IMAGE)

University of Texas at Austin, Texas Advanced Computing Center

Yin and Yang of Raf Inhibition

Caption

Scientists are using powerful supercomputers to uncover the mechanism that activates cell mutations found in about 50 percent of melanomas. Molecular dynamics simulations on TACC's Stampede2 supercomputer tested the stability of the structure of B-Raf:14-3-3 complex, which when mutated is linked to skin cancer. The study authors compare the B-Raf dimer to the Chinese yin-yang circular symbol of interconnected opposites joined at the tail.

Credit

Karandur et al., TACC

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