Figure (IMAGE)

Osaka University

Figure

Caption

Model of recurrent type I IFN production in SLE patients: Double-stranded DNA in AdMVs stimulate the cGAS-STING signaling pathway in macrophages and non-hematopoietic cells, leading to overproduction of IFN-I. Secreted IFN-I, in turn, activates other immune cells, such as B and T lymphocytes, and promotes secretion of autoantibodies that cause tissue damage in various organs. The tissue damage promotes apoptosis of damaged cells, resulting in further AdMV production, which perpetuates IFN-I production in SLE.

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Osaka University

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