Illustration of DNA Frameworks for Assembling Bioactive Proteins into Ordered 2D and 3D Arrays (IMAGE)
Caption
An illustration showing the approach for assembling biologically functional proteins into ordered 2D and 3D arrays through programmable octahedral-shaped DNA frameworks. These frameworks can host and control the placement of the proteins internally -- for example, at the center (1) or off-center (2) -- and be encoded with specific sequences externally (color coding scheme) to create desired 2-D and 3-D lattices. For example, red only connects to red, blue to blue, and so on. The team demonstrated the preserved biological activity of ferritin lattices by adding a compound (ascorbate) that induced the release of iron irons forming the ferritin core.
Credit
<em>Nature Communications</em> volume 12, Article number: 3702 (2021)
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