Harmful AP-1 (blue) acts as a roadblock to healthy gene transcription (left-hand image) but when bound to cancer-fighting peptides (red & white), it is knocked off DNA sites (yellow) and permanently suppressed (right-hand image), resulting in healthy cell function. (IMAGE)
Caption
In a process known as transcription, DNA is transcribed into messenger RNA (mRNA) by the enzyme RNA polymerase (RNAP). During TBS, AP-1 molecules (blue) sit on key DNA sites (yellow), acting as roadblocks to this process resulting in cell death. The roadblock is removed (right-hand image) when peptide molecules (red and white) bind to AP-1, both knocking it off the DNA strand and sequestering it. The cell then survives.
Credit
Neil Kad, Professor of Molecular Biophysics, University of Kent
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