Working model for direct and indirect mechanisms of mammary serotonin (5HT)-stimulated improvements of Ca metabolism (IMAGE)

Elsevier

Working model for direct and indirect mechanisms of mammary serotonin (5HT)-stimulated improvements of Ca metabolism

Caption

Increased 5HT concentrations induce changes in key Ca transporters (ORAI1 and PMCA2). Increased expression of ORAI1 and PMCA2 will result in Ca excreted into milk, resulting in transient hypocalcemia (A). The resulting declines in blood Ca concentrations inactivate the Ca sensing receptor (CaSR), stimulating synthesis and secretion of parathyroid hormone-related protein (PTHrP) by the mammary gland, indirectly modulating Ca metabolism (B). Serotonin may directly stimulate mammary-derived PTHrP (C). Upon release into circulation, PTHrP may then travel to bone, bind, and act to liberate bone Ca stores to recover blood Ca concentrations (D).

Credit

Journal of Dairy Science

Usage Restrictions

Please include attribution

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.