Microbiome-based therapeutic for Parkinson’s Disease (IMAGE)

Experimental Biology

Microbiome-based therapeutic for Parkinson’s Disease

Caption

A probiotic was engineered to endogenously produce L-DOPA from tyrosine using recombinant 4-hydrophenylacetate 3-monooxygenase and FAD reductase genes. The L-DOPA live-biotherapeutic is pre-activated and orally administered. Tests of the new drug delivery approach reveal steady-state plasma L-DOPA levels and brain dopamine levels in pre-clinical animal models.

Credit

Piyush Padhi, University of Georgia

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License

CC BY

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