MB, NGB, and CYGB but not HB suppress COL1A1 promoter activity and inhibits liver fibrosis (IMAGE)

Osaka City University

MB, NGB, and CYGB but not HB suppress COL1A1 promoter activity and inhibits liver fibrosis

Caption

MB, NGB, and CYGB, but not HB, were endocytosed into the HSCs via endocytosis pathway, scavenged intracellular ROS, and suppressed COL1A1 promoter activity, resulting in HSC deactivation and inhibition of collagen production in vitro and in vivo. Globin therapy could be utilized as anti-fibrotic therapy in human liver cirrhosis.

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Osaka City University

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