Fig.1　 Seed-dependent accumulation of phosphorylated alpha-synuclein in the brain of wild-type mice. (IMAGE)

Tokyo Metropolitan Institute of Medical Science

Fig.1　 Seed-dependent accumulation of phosphorylated alpha-synuclein in the brain of wild-type mice.

Caption

a. Localization of phosphorylated α-synuclein (αSyn) at 3, 5, and 14 days after injection of α-synuclein aggregates formed in vitro into the hippocampus of wild-type mice (upper panel). Co-staining images with neural cell body marker (NeuN) (lower panel).¬Aggregated form of phosphorylated α-synuclein accumulates in the neuronal cell bodies at 14 days after injection (arrow head). b. Co-localization of phosphorylated α-synuclein with various neuronal markers at 5 days after injection. Phosphorylated α-synuclein did not co-localize with neuronal cell body markers (NeuN; left), but did co-localize with synaptic markers (synapsin I; center) and axonal markers (tau; right).

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