The pathway to EMT in mannitol treatment (IMAGE)

Tokyo Metropolitan University

The pathway to EMT in mannitol treatment

Caption

Hyperosmotic stress leads to a reorganization of actin structure in tubular epithelial cells, with elevated incorporation of alpha-SMA and reorganization of focal adhesions. This leads to EMT, as evidenced by a decrease in E-cadherin expression. (Bottom) Fluorescence signal showing the decrease in E-cadherin (left) and increase in alpha-SMA (right) in kidney cells after mannitol treatment.

Credit

Tokyo Metropolitan University

Usage Restrictions

Can be used with credit.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.