Immune cells that clear away Alzheimer's disease protein are controlled by circadian rhythms (IMAGE)
Caption
Image Caption: The image of a clock with brightfield macrophage images around it shows how circadian changes of cell surface heparan sulfate proteoglycans, shown in pink, impedes phagocytosis of fluorescently labeled amyloid-beta, shown in green. As time goes on, and we have a reduction in heparan sulfate proteoglycans, we see an increase in phagocytosis, demonstrated by the bright green cells shown on the left of the clock. This image was made using our fluorescent microscopy cell images with an artistic rendering of the heparan sulfate proteoglycans from the app, Wombo. The clock was made using photoshop and clip art.
Credit
Gretchen Clark, made using Wombo (CC-BY 4.0, https://creativecommons.org/licenses/by/4.0/)
Usage Restrictions
Credit must be given to the creator.
License
CC BY