Scripps Research discovery illuminates how brain cells die in prion diseases (IMAGE)
Caption
Neurons grown in culture expressing a mutant prion protein (cyan) that cause prion disease in humans. These neurons display swollen axons that contain toxic mutant prion protein aggregates. Chassefeyre et al. identified genes that account for the formation of these aggregates and showed that reducing their function can inhibit aggregate formation and prevent neuronal dysfunction.
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Adriaan Verhelle and Yin Wu (Scripps Research)
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