The kinetics hypothesis indicates a rACoA pathway and a complete rTCA cycle do not coexist inside the cell of LUCA (IMAGE)

Toyohashi University of Technology (TUT)

The kinetics hypothesis indicates a rACoA pathway and a complete rTCA cycle do not coexist inside the cell of LUCA

Caption

(a) Schematic phylogenic diagram of bacteria, archaea, and eukaryotic organisms branching from the Last Universal Common Ancestor (LUCA), (b) When the rACoA pathway and the rTCA cycle coexist in a single cell and acetyl-CoA (ACoA) is input into the rTCA cycle, a partially impaired TCA pathway is developed due to competition between chemical reaction fluxes. The blue pathway indicates the impaired part.

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