Cholesterol metabolism in macrophages: New results offer insight into lung cancer (IMAGE)
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Significant changes in lipid metabolism are known to occur in cells associated with non-small-cell lung carcinoma – the most common form of lung cancer. The pharmaceutical scientists Alexandra K. Kiemer and Jessica Hoppstädter from Saarland University have discovered that the lipid and cholesterol metabolism of immune cells that collaborate with the tumour is severely compromised – in contrast to what is observed in the tumour tissue itself. The cell culture model they developed has allowed them to examine parameters that correlate with tumour growth. The goal now is to find new therapeutic approaches. The research team has published its findings in the journal EBioMedicine.
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Credit: Iris Maurer
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