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The University of Hong Kong

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Upper panel: The process of foreign DNA microinjection and artificial chromosome formation in C. elegans in vivo. The cellular mechanism of de novo holocentromere formation on artificial chromosomes (current findings). Lower panel: The iterative process of designing, constructing, sequencing and analysing worm artificial chromosomes for phenotypic screening and other applications. (Image credit: Upper panel: Nucleic Acids Research, Lower panel: by Lin Zhongyang.)

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The University of Hong Kong

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