Researchers Illuminate the Working Mechanism of Important Drug Target Proteins (IMAGE)
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Seven transmembrane receptors are typically thought to signal through G-proteins and arrestins. Researchers have now discovered that, upon agonist binding, some seven transmembrane receptors signal exclusively through arrestin but not G-proteins. These findings, therefore, establish such receptors as arrestin-coupled receptors (ACRs) in contrast with conventional G protein-coupled receptors (GPCRs).
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Arun K. Shukla
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