Model showing how fatty acid metabolism triggers lipid peroxidation and regulates hepatitis C virus replication (IMAGE)

Tokyo Metropolitan Institute of Medical Science

Model showing how fatty acid metabolism triggers lipid peroxidation and regulates hepatitis C virus replication

Caption

Model showing how fatty acid metabolism triggers lipid peroxidation and regulates hepatitis C virus replication. Production of polyunsaturated fatty acids (PUFAs) is regulated predominantly by FADS2. PUFAs react with reactive oxygen species produced by iron and undergo lipid peroxidation. Lipid peroxidation alters conformation of the viral replication machinery, thereby inhibiting its function. Thus, ferroptosis inducers, drugs that enhance oxidation of PUFAs, increase the efficacy of antiviral drugs.

Credit

Daisuke Yamane, D.V.M., Ph.D., Tokyo Metropolitan Institute of Medical Science

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