Figure 9 (IMAGE)

Impact Journals LLC

Figure 9

Caption

Genes upregulated in aging which are targeted by miRNAs from Meg3-Mirg locus. DNMT2/TRDMT1 gene knockout modulated DOX- and ETOPO-induced senescence program in glioblastoma cells as judged by affected SIPS response (lowered number of SA-beta-gal-positive cells and diminished levels of nuclear p21), apoptosis resistance, increased ROS production, increased DSBs, impaired RNA-mediated DDR and autophagic response, modulated SASP and the levels of NSUN proteins. Thus, DNMT2/TRDMT1 gene knockout may result in the promotion of some selected adverse side effects mediated by drug-stimulated senescence.

Credit

Correspondence to: Anna Lewinska email: lewinska@ur.edu.pl and Maciej Wnuk email: mwnuk@ur.edu.pl

Usage Restrictions

Credit must be given to the creator.

License

CC BY

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.